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T Otsuki Selected Research

KF58333

12/2001A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts.

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T Otsuki Research Topics

Disease

8Breast Neoplasms (Breast Cancer)
01/2004 - 01/2000
7Silicosis
01/2011 - 02/2000
7Neoplasms (Cancer)
01/2011 - 03/2000
5Autoimmune Diseases (Autoimmune Disease)
01/2011 - 02/2000
3Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2011 - 02/2000
3Systemic Scleroderma (Systemic Sclerosis)
01/2011 - 12/2001
3Multiple Myeloma
06/2001 - 03/2000
2Rheumatoid Arthritis
01/2011 - 10/2010
2Hypoxia (Hypoxemia)
12/2001 - 10/2001
2Genetic Translocation (Chromosomal Translocation)
09/2001 - 06/2001
2Papillary Thyroid Cancer
08/2000 - 04/2000
1Stroke (Strokes)
01/2015
1Infarction (Infarctions)
01/2015
1Pulmonary Fibrosis (Fibrosing Alveolitis)
01/2011
1Caplan Syndrome
01/2011
1Nephritis
01/2011
1Malignant Mesothelioma
01/2011
1Sclerosis
10/2010
1Glomerulonephritis
10/2010
1Lung Neoplasms (Lung Cancer)
10/2009
1Mesothelioma
10/2009
1Bone Diseases (Bone Disease)
10/2007
1Fibrosis (Cirrhosis)
10/2007
1Pneumoconiosis
05/2005
1Starvation
11/2004
1Rheumatic Diseases (Rheumatism)
12/2001
1Epstein-Barr Virus Infections
11/2001
1Fever (Fevers)
11/2001
1Fanconi Anemia (Fanconi's Anemia)
11/2001
1Lymphoma (Lymphomas)
11/2001
1Abdominal Pain (Pain, Abdominal)
11/2001
1B-Cell Lymphoma (Lymphoma, B Cell)
11/2001
1Biliary Atresia
11/2001
1Cachexia
10/2001
1Chromosome Aberrations (Chromosome Abnormalities)
09/2001
1Diffuse Scleroderma (Progressive Systemic Sclerosis)
04/2001
1Hypercalcemia (Milk Alkali Syndrome)
04/2001
1Allergic Contact Dermatitis
03/2001

Drug/Important Bio-Agent (IBA)

4AsbestosIBA
01/2011 - 05/2005
3Silicon Dioxide (Silica)FDA LinkGeneric
01/2011 - 02/2000
3AutoantibodiesIBA
12/2001 - 05/2000
3Proteins (Proteins, Gene)FDA Link
11/2001 - 02/2000
3Estrogen Receptor Modulators (Antiestrogen)IBA
10/2001 - 03/2000
3Messenger RNA (mRNA)IBA
10/2001 - 02/2000
2Fulvestrant (Faslodex)FDA Link
01/2004 - 01/2000
2HLA-DQB1 antigen (HLA DQB1)IBA
12/2001 - 04/2001
2Type I DNA Topoisomerases (Topoisomerase I)IBA
12/2001 - 04/2001
2anti-scl-70 autoantibodiesIBA
12/2001 - 04/2001
2trioctyl phosphine oxide (TOPO)IBA
12/2001 - 04/2001
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2001 - 06/2000
2RNA (Ribonucleic Acid)IBA
11/2001 - 04/2000
2Hormones (Hormone)IBA
10/2001 - 08/2000
2Estrogen ReceptorsIBA
10/2001 - 03/2000
2Estradiol (Delestrogen)FDA LinkGeneric
10/2001 - 08/2000
2Cyclin D1IBA
09/2001 - 04/2000
2ThyroglobulinFDA Link
08/2000 - 04/2000
2Fas Ligand Protein (Fas Ligand)IBA
05/2000 - 02/2000
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
03/2000 - 02/2000
2Co-Repressor ProteinsIBA
03/2000 - 02/2000
1N(6)-allyl-N(6)-cyclohexyladenosineIBA
01/2015
1Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
01/2011
1MineralsIBA
01/2011
1Aligeron (AS 2)IBA
01/2009
1Interleukin-2 Receptors (IL 2 Receptor)IBA
01/2009
1Indicators and Reagents (Reagents)IBA
01/2009
1Transforming Growth Factor beta1 (TGF beta 1)IBA
10/2007
1OsteoprotegerinIBA
10/2007
1AntioxidantsIBA
05/2005
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2005
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2004
1Cyclin-Dependent Kinases (cdk Proteins)IBA
11/2004
1ErbB Receptors (EGF Receptor)IBA
01/2004
1Tyrosine Kinase InhibitorsIBA
01/2004
1Gefitinib (Iressa)FDA Link
01/2004
1KF58333IBA
12/2001
1monorden (radicicol)IBA
12/2001
1SiliconesIBA
12/2001
1Membrane Proteins (Integral Membrane Proteins)IBA
11/2001
1Epstein-Barr Virus Nuclear AntigensIBA
11/2001
1Cyclosporine (Ciclosporin)FDA LinkGeneric
11/2001
1Tacrolimus (Prograf)FDA LinkGeneric
11/2001
1TegafurIBA
10/2001
1Estrogens (Estrogen)FDA Link
10/2001
1Progestins (Progestagens)IBA
10/2001
1Progesterone Receptors (Progesterone Receptor)IBA
10/2001
1Thymidine PhosphorylaseIBA
10/2001
1Docetaxel (Taxotere)FDA Link
10/2001
1Interleukin-6 (Interleukin 6)IBA
10/2001
1Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric
10/2001
1doxifluridineIBA
10/2001
1Cyclin D2IBA
09/2001
1Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
06/2001
1Transcription Factors (Transcription Factor)IBA
06/2001
1Parathyroid Hormone-Related ProteinIBA
04/2001
1Glycyrrhetinic Acid (Po 12)IBA
03/2001

Therapy/Procedure

5Therapeutics
10/2007 - 01/2000
1Intravenous Injections
12/2001
1Breast Implants (Breast Implant)
12/2001
1Liver Transplantation
11/2001
1Intraperitoneal Injections
10/2001